Across TCGA patient cohorts, KCNRG mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNRG-associated genes across cancer lineages are EGFR_pY1068, IGFBP2, and JNK_pT183_Y185. Each is linked with KCNRG in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNRG-to-partner and partner-to-KCNRG results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNRG→partner) and Y-score (partner→KCNRG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.293	-3.321	.015	.010	3	1
UCEC	IGFBP2 →	-0.873	-2.999	.005	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.218	-3.169	.007	.019	3	1
UCEC	MSH6 →	-0.422	-3.169	.008	.018	3	1
UCEC	p90 RSK →	+0.233	+3.598	.011	.001	3	1
UCEC	Shc_pY317 →	-0.209	-3.584	.004	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Exploration

KCNRG survival (RNA) · tumor vs normal (RNA) · all KCNRG data types