potassium two pore domain channel subfamily K member 15Genealiases: K2p15.1 · KCNK11 · KCNK14 · KT3.3 · TASK-5 · TASK5
Q-omics provides the consensus-scored KCNK15 profile across patient tissues and cancer cell-line models. KCNK15 expression is associated with patient survival in 19 of 34 cancer types, with the highest sampling consensus in BRCA. Among the 18 cancer types available for tumor–normal comparison, KCNK15 is differentially expressed in 10, with the highest sampling consensus in KIRC. Additionally, KCNK15 RNA expression shows 12,842 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight BRCA, KIRC, and THYM as cancer lineages where KCNK15 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for KCNK15 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes KCNK15 survival associations across molecular data types. KCNK15 RNA expression shows survival associations in the most cancer types (19), followed by mutation status (3) and mass-spec protein abundance (1). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible KCNK15 RNA expression–survival associations across cancer types. High KCNK15 expression shows unfavorable associations in LGG, COAD and CESC, but favorable associations in BRCA, THCA and SARC. The BRCA Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify BRCA as the clearest survival context for KCNK15 RNA expression.
This table summarizes KCNK15 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 10, while mass-spec protein shows differences in 1. The strongest signals are observed in KIRC for RNA and LSCC for protein.
This table ranks reproducible tumor–normal expression differences for KCNK15. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. KCNK15 shows lower tumor expression in KIRC and higher tumor expression in THCA, COAD, BRCA, PAAD and CHOL. The KIRC box plot shows higher KCNK15 RNA expression in normal versus tumor tissue (log2 FC = −1.185, t-test p < 0.001).
This table shows molecular features associated with KCNK15 in patient tissues and cancer cell lines. In patient samples, KCNK15 shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set. In cancer cell lines, KCNK15 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in SOFT_TISSUE, while CRISPR and shRNA rows add functional-dependency signals in OVARY and LARGE_INTESTINE.
