KCNK15

Across TCGA patient cohorts, KCNK15 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNK15-associated genes across cancer lineages are Ku80, eEF2, and ACC_pS79. Each is linked with KCNK15 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNK15-to-partner and partner-to-KCNK15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by KCNK15-low versus KCNK15-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNK15→partner) and Y-score (partner→KCNK15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.331	+3.472	.005	.002	3	2
UCEC	eEF2 →	+0.456	+2.321	.011	.035	3	1
UCEC	ACC_pS79 →	+0.376	+2.321	.031	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.193	-2.308	.022	.036	3	1
UCEC	STAT3_pY705 →	-0.473	-3.321	<.001	.009	3	1
UCEC	ATM →	-0.546	-2.321	.016	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Ku80 by KCNK15 expression — UCEC

Explore this box plot interactively →