potassium two pore domain channel subfamily K member 12Genealiases: K2p12.1 · THIK-2 · THIK2
Q-omics provides the consensus-scored KCNK12 profile across patient tissues and cancer cell-line models. KCNK12 expression is associated with patient survival in 19 of 34 cancer types, with the highest sampling consensus in KIRP. Among the 18 cancer types available for tumor–normal comparison, KCNK12 is differentially expressed in 12, with the highest sampling consensus in LUAD. Additionally, KCNK12 RNA expression shows 18,538 significant protein co-abundance associations, with the highest sampling consensus in LSCC. Together, these results highlight KIRP, LUAD, and LSCC as cancer lineages where KCNK12 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for KCNK12 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes KCNK12 survival associations across molecular data types. KCNK12 RNA expression shows survival associations in the most cancer types (19), followed by mutation status (1). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible KCNK12 RNA expression–survival associations across cancer types. High KCNK12 expression shows unfavorable associations in KIRP, MESO, UVM and BRCA, but favorable associations in LGG and ACC. The KIRP Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRP as the clearest survival context for KCNK12 RNA expression.
This table summarizes KCNK12 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 12. The strongest signals are observed in LUAD for RNA.
This table ranks reproducible tumor–normal expression differences for KCNK12. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. KCNK12 shows lower tumor expression in KICH and COAD and higher tumor expression in LUAD, LUSC, STAD and CHOL. The LUAD box plot shows higher KCNK12 RNA expression in tumor versus normal tissue (log2 FC = +0.538, t-test p < 0.001).
This table shows molecular features associated with KCNK12 in patient tissues and cancer cell lines. In patient samples, KCNK12 shows the broadest associations at the RNA and protein expression levels, with LSCC recurring as the lineage with the largest associated feature set. In cancer cell lines, KCNK12 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LUNG_SCLC, while CRISPR and shRNA rows add functional-dependency signals in OESOPHAGUS and BLOOD_Lymphoma.
