Across TCGA patient cohorts, KCNK12 mutation is significantly associated with the RNA expression of many other genes, with 71 significant associations in total. COAD shows the largest number of these associations.

The most reproducible KCNK12-associated genes across cancer lineages are SNORD116-11, RNU6-369P, and RNU6-1252P. Each is linked with KCNK12 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNK12-to-partner and partner-to-KCNK12 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNK12→partner) and Y-score (partner→KCNK12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SNORD116-11 →	+0.378	+6.219	<.001	<.001	3	2
COAD	RNU6-369P →	+0.411	+7.741	<.001	.009	3	1
COAD	RNU6-1252P →	+0.526	+7.741	<.001	.009	3	1
COAD	RNU6-832P →	+0.394	+7.741	<.001	.009	3	1
COAD	RNU6-654P →	+1.311	+7.741	<.001	.009	3	1
COAD	RNU1-84P →	+1.267	+7.741	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 71 associations by consensus.

Exploration

KCNK12 survival (RNA) · tumor vs normal (RNA) · all KCNK12 data types