potassium voltage-gated channel interacting protein 1Genealiases: KCHIP1 · VABP
Q-omics provides the consensus-scored KCNIP1 profile across patient tissues and cancer cell-line models. KCNIP1 expression is associated with patient survival in 27 of 34 cancer types, with the highest sampling consensus in BRCA. Among the 18 cancer types available for tumor–normal comparison, KCNIP1 is differentially expressed in 13, with the highest sampling consensus in KIRC. Additionally, KCNIP1 RNA expression shows 12,148 significant gene co-expression associations, with the highest sampling consensus in TGCT. Together, these results highlight BRCA, KIRC, and TGCT as cancer lineages where KCNIP1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for KCNIP1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes KCNIP1 survival associations across molecular data types. KCNIP1 RNA expression shows survival associations in the most cancer types (27), followed by mutation status (4) and mass-spec protein abundance (1). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible KCNIP1 RNA expression–survival associations across cancer types. High KCNIP1 expression shows unfavorable associations in LUSC, LAML and LUAD, but favorable associations in BRCA, CESC and OV. The BRCA Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify BRCA as the clearest survival context for KCNIP1 RNA expression.
This table summarizes KCNIP1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 13. The strongest signals are observed in THCA for RNA.
This table ranks reproducible tumor–normal expression differences for KCNIP1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. KCNIP1 shows lower tumor expression in KIRC, THCA, COAD, LUAD, LUSC and KIRP. The KIRC box plot shows higher KCNIP1 RNA expression in normal versus tumor tissue (log2 FC = −1.380, t-test p < 0.001).
This table shows molecular features associated with KCNIP1 in patient tissues and cancer cell lines. In patient samples, KCNIP1 shows the broadest associations at the RNA and protein expression levels, with TGCT recurring as the lineage with the largest associated feature set. In cancer cell lines, KCNIP1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in PANCREAS, while CRISPR and shRNA rows add functional-dependency signals in BLOOD_Leukemia and LARGE_INTESTINE.
