KCNIP1

Across TCGA pan-cancer cohorts, KCNIP1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of KCNIP1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where KCNIP1 RNA is repressed in tumor relative to normal tissue. In most cancer types KCNIP1 is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, THCA, and COAD are the cancer types where KCNIP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KCNIP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	III,IV	−1.380	<.001	11	view →
THCA	Female	III,IV	−0.954	<.001	11	view →
COAD	Male	II,III,IV	−0.330	<.001	10	view →
LUAD	Female	III,IV	−1.241	<.001	8	view →
LUSC	Female	II,III,IV	−1.262	<.001	7	view →
KIRP	All	II,III,IV	−1.194	<.001	7	view →
UCEC	All	III,IV	−1.151	<.001	6	view →
BRCA	All	III,IV	−0.648	<.001	6	view →
BLCA	All	IV	−0.561	.010	5	view →
HNSC	Male	All	−0.128	.026	5	view →
KICH	Male	All	−1.057	.001	4	view →
READ	Female	All	−0.584	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

KCNIP1–KIRC

Open the KIRC breakdown →