potassium voltage-gated channel subfamily H member 8Genealiases: ELK · ELK1 · Kv12.1 · elk3 · hElk-1
Q-omics provides the consensus-scored KCNH8 profile across patient tissues and cancer cell-line models. KCNH8 expression is associated with patient survival in 24 of 34 cancer types, with the highest sampling consensus in UCS. Among the 18 cancer types available for tumor–normal comparison, KCNH8 is differentially expressed in 14, with the highest sampling consensus in COAD. Additionally, KCNH8 RNA expression shows 19,664 significant protein co-abundance associations, with the highest sampling consensus in GBM. Together, these results highlight UCS, COAD, and GBM as cancer lineages where KCNH8 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for KCNH8 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes KCNH8 survival associations across molecular data types. KCNH8 RNA expression shows survival associations in the most cancer types (24), followed by mutation status (9). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible KCNH8 RNA expression–survival associations across cancer types. High KCNH8 expression shows unfavorable associations in THCA, but favorable associations in UCS, LGG, PAAD, BRCA and LUSC. The UCS Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p = .018). Together, the overview and detailed table identify UCS as the clearest survival context for KCNH8 RNA expression.
This table summarizes KCNH8 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 14. The strongest signals are observed in COAD for RNA.
This table ranks reproducible tumor–normal expression differences for KCNH8. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. KCNH8 shows lower tumor expression in BRCA and THCA and higher tumor expression in COAD, KIRP, STAD and LUSC. The COAD box plot shows higher KCNH8 RNA expression in tumor versus normal tissue (log2 FC = +1.716, t-test p < 0.001).
This table shows molecular features associated with KCNH8 in patient tissues and cancer cell lines. In patient samples, KCNH8 shows the broadest associations at the RNA and protein expression levels, with GBM recurring as the lineage with the largest associated feature set. In cancer cell lines, KCNH8 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in UPPER_AERODIGESTIVE_TRACT, while CRISPR and shRNA rows add functional-dependency signals in SKIN and BLOOD_Leukemia.
