Across TCGA cell cohorts, KCNH8 mutation is significantly associated with the RNA expression of many other genes, with 989 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KCNH8-associated genes across cancer lineages are SEMG1, FGF6, and KDM4E. Each is linked with KCNH8 in more than 2 cancer types. Because this analysis shows association rather than direction, both KCNH8-to-partner and partner-to-KCNH8 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNH8→partner) and Y-score (partner→KCNH8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SEMG1 →	+0.010	+3.169	.002	.005	3	2
SKIN	FGF6 →	+0.041	+3.217	<.001	.006	3	2
STOMACH	KDM4E →	+0.008	+3.432	.005	.008	3	2
LARGE_INTESTINE	DOCK5 →	+0.852	+2.936	.001	<.001	3	2
LARGE_INTESTINE	GUF1 →	+0.455	+2.244	<.001	.003	3	2
LARGE_INTESTINE	RAB28 →	+0.446	+2.652	.007	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 989 associations by consensus.

Exploration

KCNH8 survival (RNA) · tumor vs normal (RNA) · all KCNH8 data types