Across TCGA patient cohorts, KCNH8 mutation is significantly associated with the total protein of many other genes, with 77 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNH8-associated genes across cancer lineages are 4E-BP1, FoxM1, and GAPDH. Each is linked with KCNH8 in more than 3 cancer types. Because this analysis shows association rather than direction, both KCNH8-to-partner and partner-to-KCNH8 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNH8→partner) and Y-score (partner→KCNH8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.219	+2.087	.002	.004	3	4
LUAD	FoxM1 →	+0.382	+2.820	<.001	.001	3	3
SKCM	GAPDH →	+0.585	+2.321	.007	.032	3	3
UCEC	JNK2 →	+0.198	+1.584	<.001	<.001	3	3
UCEC	Heregulin →	-0.084	-1.266	.012	.049	3	3
UCEC	PCNA →	+0.215	+1.765	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 77 associations by consensus.

Exploration

KCNH8 survival (RNA) · tumor vs normal (RNA) · all KCNH8 data types