potassium voltage-gated channel subfamily H member 7Genealiases: ERG3 · HERG3 · Kv11.3
Q-omics provides the consensus-scored KCNH7 profile across patient tissues and cancer cell-line models. KCNH7 expression is associated with patient survival in 24 of 34 cancer types, with the highest sampling consensus in UVM. Among the 18 cancer types available for tumor–normal comparison, KCNH7 is differentially expressed in 11, with the highest sampling consensus in KIRC. Additionally, KCNH7 RNA expression shows 17,373 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight UVM, KIRC, and THYM as cancer lineages where KCNH7 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for KCNH7 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes KCNH7 survival associations across molecular data types. KCNH7 RNA expression shows survival associations in the most cancer types (24), followed by mutation status (5) and mass-spec protein abundance (1). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible KCNH7 RNA expression–survival associations across cancer types. High KCNH7 expression shows unfavorable associations in UVM, THCA and LUSC, but favorable associations in SKCM, KIRC and MESO. The UVM Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify UVM as the clearest survival context for KCNH7 RNA expression.
This table summarizes KCNH7 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 11, while mass-spec protein shows differences in 2. The strongest signals are observed in KIRC for RNA and COAD for protein.
This table ranks reproducible tumor–normal expression differences for KCNH7. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. KCNH7 shows lower tumor expression in KIRC, KICH, LIHC, CHOL, LUSC and UCEC. The KIRC box plot shows higher KCNH7 RNA expression in normal versus tumor tissue (log2 FC = −0.133, t-test p < 0.001).
This table shows molecular features associated with KCNH7 in patient tissues and cancer cell lines. In patient samples, KCNH7 shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set. In cancer cell lines, KCNH7 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in CNS, while CRISPR and shRNA rows add functional-dependency signals in STOMACH and BLOOD_Leukemia.
