Across TCGA cell cohorts, KCNH7 mutation is significantly associated with the RNA expression of many other genes, with 362 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible KCNH7-associated genes across cancer lineages are LAMB3, LRRC52, and OXT. Each is linked with KCNH7 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNH7-to-partner and partner-to-KCNH7 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNH7→partner) and Y-score (partner→KCNH7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	LAMB3 →	-1.535	-3.321	.007	.003	3	2
SOFT_TISSUE	LRRC52 →	+0.022	+4.930	<.001	.008	3	1
LUNG_NSCLC_LUSC	OXT →	+0.123	+3.000	.007	.006	3	1
LUNG_NSCLC_LUSC	KCNK17 →	+0.048	+3.321	<.001	.007	3	1
LUNG_NSCLC_LUSC	C22orf42 →	+0.049	+3.137	.007	.003	3	1
BLOOD_Leukemia	ZDHHC15 →	+0.530	+3.813	.005	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 362 associations by consensus.

Exploration

KCNH7 survival (RNA) · tumor vs normal (RNA) · all KCNH7 data types