Across TCGA pan-cancer cohorts, KCNH7 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of KCNH7’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where KCNH7 RNA is repressed in tumor relative to normal tissue. In most cancer types KCNH7 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.
KIRC, KICH, and LIHC are the cancer types where KCNH7 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KCNH7 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.