Across TCGA patient cohorts, KCNH7 mutation is significantly associated with the RNA expression of many other genes, with 7,440 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible KCNH7-associated genes across cancer lineages are CPSF3, FEN1, and OIP5. Each is linked with KCNH7 in more than 5 cancer types. Because this analysis shows association rather than direction, both KCNH7-to-partner and partner-to-KCNH7 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNH7→partner) and Y-score (partner→KCNH7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	CPSF3 →	+0.335	+1.212	<.001	<.001	3	6
LUAD	FEN1 →	+0.611	+2.011	.001	.005	3	5
LUAD	OIP5 →	+0.913	+3.723	<.001	<.001	3	5
UCEC	LRRC42 →	+0.408	+2.000	.002	<.001	3	5
LUAD	RAD51 →	+0.774	+2.942	<.001	<.001	3	5
LUAD	SPAG5 →	+0.865	+3.620	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,440 associations by consensus.

Exploration

KCNH7 survival (RNA) · tumor vs normal (RNA) · all KCNH7 data types