potassium voltage-gated channel subfamily C member 1Genealiases: EPM7 · KV3.1 · KV4 · NGK2
Q-omics provides the consensus-scored KCNC1 profile across patient tissues and cancer cell-line models. KCNC1 expression is associated with patient survival in 26 of 34 cancer types, with the highest sampling consensus in KIRP. Among the 18 cancer types available for tumor–normal comparison, KCNC1 is differentially expressed in 11, with the highest sampling consensus in COAD. Additionally, KCNC1 RNA expression shows 17,543 significant gene co-expression associations, with the highest sampling consensus in TGCT. Together, these results highlight KIRP, COAD, and TGCT as cancer lineages where KCNC1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for KCNC1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes KCNC1 survival associations across molecular data types. KCNC1 RNA expression shows survival associations in the most cancer types (26), followed by mutation status (10) and mass-spec protein abundance (1). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible KCNC1 RNA expression–survival associations across cancer types. High KCNC1 expression shows unfavorable associations in KIRP, KICH, ACC and LUSC, but favorable associations in PAAD and LGG. The KIRP Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRP as the clearest survival context for KCNC1 RNA expression.
This table summarizes KCNC1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 11. The strongest signals are observed in COAD for RNA.
This table ranks reproducible tumor–normal expression differences for KCNC1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. KCNC1 shows lower tumor expression in COAD, READ and HNSC and higher tumor expression in KICH, KIRP and LUSC. The COAD box plot shows higher KCNC1 RNA expression in normal versus tumor tissue (log2 FC = −0.118, t-test p < 0.001).
This table shows molecular features associated with KCNC1 in patient tissues and cancer cell lines. In patient samples, KCNC1 shows the broadest associations at the RNA and protein expression levels, with TGCT recurring as the lineage with the largest associated feature set. In cancer cell lines, KCNC1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in SOFT_TISSUE, while CRISPR and shRNA rows add functional-dependency signals in OESOPHAGUS and BLOOD_Leukemia.
