KCNC1

Across TCGA cell cohorts, KCNC1 mutation is significantly associated with the RNA expression of many other genes, with 733 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KCNC1-associated genes across cancer lineages are SRRM1, C20orf85, and CYP39A1. Each is linked with KCNC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNC1-to-partner and partner-to-KCNC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SRRM1 grouped by KCNC1-low versus KCNC1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNC1→partner) and Y-score (partner→KCNC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SRRM1 →	+0.684	+3.502	.002	.001	3	2
BLOOD_Leukemia	C20orf85 →	+0.033	+4.384	<.001	.006	3	1
BLOOD_Leukemia	CYP39A1 →	+0.183	+3.769	<.001	.008	3	1
BLOOD_Leukemia	DIRAS2 →	+0.090	+4.087	<.001	.009	3	1
BLOOD_Leukemia	PRND →	+0.009	+3.874	<.001	.005	3	1
BLOOD_Leukemia	OR10K2 →	+0.043	+3.705	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 733 associations by consensus.

SRRM1 by KCNC1 expression — LARGE_INTESTINE

Explore this box plot interactively →