KCNC1

Across TCGA patient cohorts, KCNC1 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNC1-associated genes across cancer lineages are ATM, eIF4E, and MEK1. Each is linked with KCNC1 in more than 3 cancer types. Because this analysis shows association rather than direction, both KCNC1-to-partner and partner-to-KCNC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by KCNC1-low versus KCNC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNC1→partner) and Y-score (partner→KCNC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.601	-2.099	<.001	<.001	3	4
UCEC	eIF4E →	+0.180	+2.169	.003	.003	3	3
UCEC	MEK1 →	+0.394	+1.857	<.001	<.001	3	3
UCEC	ASNS →	+0.298	+2.070	.005	.001	3	3
SKCM	Cyclin-B1 →	+0.559	+3.169	.011	.019	2	4
UCEC	Di-Ras3 →	-0.167	-1.857	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

ATM by KCNC1 expression — UCEC

Explore this box plot interactively →