homer scaffold protein 3Genealiases: HOMER-3 · VESL3
Q-omics provides the consensus-scored HOMER3 profile across patient tissues and cancer cell-line models. HOMER3 expression is associated with patient survival in 23 of 34 cancer types, with the highest sampling consensus in ACC. Among the 18 cancer types available for tumor–normal comparison, HOMER3 is differentially expressed in 18, with the highest sampling consensus in HNSC. Additionally, HOMER3 protein abundance shows 22,123 significant protein co-abundance associations, with the highest sampling consensus in HNSC. Together, these results highlight ACC, and HNSC as cancer lineages where HOMER3 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for HOMER3 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes HOMER3 survival associations across molecular data types. HOMER3 RNA expression shows survival associations in the most cancer types (23), followed by mutation status (2) and mass-spec protein abundance (8). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible HOMER3 RNA expression–survival associations across cancer types. High HOMER3 expression shows unfavorable associations in ACC, MESO, COAD, LIHC and LGG, but favorable associations in ESCA. The ACC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify ACC as the clearest survival context for HOMER3 RNA expression.
This table summarizes HOMER3 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 18, while mass-spec protein shows differences in 8. The strongest signals are observed in HNSC for RNA and HNSC for protein.
This table ranks reproducible tumor–normal expression differences for HOMER3. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. HOMER3 shows higher tumor expression in HNSC, KIRP, LIHC, LUAD, BLCA and KIRC. The HNSC box plot shows higher HOMER3 RNA expression in tumor versus normal tissue (log2 FC = +2.317, t-test p < 0.001).
This table shows molecular features associated with HOMER3 in patient tissues and cancer cell lines. In patient samples, HOMER3 shows the broadest associations at the RNA and protein expression levels, with HNSC recurring as the lineage with the largest associated feature set. In cancer cell lines, HOMER3 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in BREAST, while CRISPR and shRNA rows add functional-dependency signals in LIVER and LARGE_INTESTINE.
