HOMER3

Across TCGA patient cohorts, HOMER3 mutation is significantly associated with the immune_cell of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HOMER3-associated genes across cancer lineages are CD4+ Tcm, MSC, and Basophils. Each is linked with HOMER3 in more than 1 cancer types. Because this analysis shows association rather than direction, both HOMER3-to-partner and partner-to-HOMER3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD4+ Tcm grouped by HOMER3-low versus HOMER3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOMER3→partner) and Y-score (partner→HOMER3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CD4+ Tcm →	+0.002	+5.419	.042	.027	3	1
UCEC	MSC →	+0.336	+3.000	.005	.037	3	1
UCEC	Basophils →	+0.233	+3.000	.017	.037	3	1
UCEC	Smooth muscle →	-0.203	-2.989	.005	.037	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

CD4+ Tcm by HOMER3 expression — COAD

Explore this box plot interactively →