HOMER3

Across TCGA patient cohorts, HOMER3 mutation is significantly associated with the RNA expression of many other genes, with 68 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HOMER3-associated genes across cancer lineages are MLLT10P2, FDX1P2, and RNA5SP212. Each is linked with HOMER3 in more than 2 cancer types. Because this analysis shows association rather than direction, both HOMER3-to-partner and partner-to-HOMER3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MLLT10P2 grouped by HOMER3-low versus HOMER3-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HOMER3→partner) and Y-score (partner→HOMER3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	MLLT10P2 →	+0.132	+5.669	<.001	.003	3	3
CESC	FDX1P2 →	+0.094	+5.812	<.001	.003	3	2
UCEC	RNA5SP212 →	+0.712	+3.186	<.001	.008	3	2
UCEC	RN7SKP132 →	+0.114	+4.069	<.001	.008	3	2
SKCM	RNU6-775P →	+0.358	+7.816	<.001	.008	3	2
LGG	USP9YP10 →	+0.049	+7.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 68 associations by consensus.

MLLT10P2 by HOMER3 expression — CESC

Explore this box plot interactively →