Q-omics provides the consensus-scored HAAO profile across patient tissues and cancer cell-line models. HAAO expression is associated with patient survival in 24 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, HAAO is differentially expressed in 13, with the highest sampling consensus in BLCA. Additionally, HAAO protein abundance shows 28,663 significant protein co-abundance associations, with the highest sampling consensus in LSCC. Together, these results highlight KIRC, BLCA, and LSCC as cancer lineages where HAAO shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for HAAO — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes HAAO survival associations across molecular data types. HAAO RNA expression shows survival associations in the most cancer types (24), followed by mutation status (5) and mass-spec protein abundance (6). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible HAAO RNA expression–survival associations across cancer types. High HAAO expression shows favorable associations in KIRC, UVM, READ, KIRP, OV and HNSC. The KIRC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for HAAO RNA expression.
This table summarizes HAAO tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 13, while mass-spec protein shows differences in 7. The strongest signals are observed in KIRC for RNA and HNSC for protein.
This table ranks reproducible tumor–normal expression differences for HAAO. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. HAAO shows lower tumor expression in BLCA, KICH, LIHC, LUAD and HNSC and higher tumor expression in KIRC. The BLCA box plot shows higher HAAO RNA expression in normal versus tumor tissue (log2 FC = −3.097, t-test p < 0.001).
This table shows molecular features associated with HAAO in patient tissues and cancer cell lines. In patient samples, HAAO shows the broadest associations at the RNA and protein expression levels, with LSCC recurring as the lineage with the largest associated feature set. In cancer cell lines, HAAO RNA and mutation anchors are most strongly linked to RNA-expression features, especially in OESOPHAGUS, while CRISPR and shRNA rows add functional-dependency signals in LARGE_INTESTINE and BLOOD_Leukemia.
