HAAO

Across TCGA pan-cancer cohorts, HAAO mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated HAAO data layer compared with 24 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher HAAO mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated HAAO expression acts as an unfavorable survival marker, although some lineages such as PDAC and LUAD show a favorable association.

PDAC, LUAD, and CCRCC are the cancer types where HAAO mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	All	0.512	0.296	<.001	75	view →
LUAD	DFS	Quartile	All	0.887	0.458	<.001	38	view →
CCRCC	OS	Quartile	III,IV	0.850	0.462	.022	11	view →
HNSC	DFS	Tertile	All	0.532	0.759	.017	7	view →
UCEC	DFS	Median	II,III,IV	0.536	0.880	.044	4	view →
LSCC	OS	Tertile	All	0.699	0.903	.021	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

HAAO–PDAC (DFS)

Open the PDAC breakdown →