G protein-coupled receptor 143Genealiases: NYS6 · OA1
Q-omics provides the consensus-scored GPR143 profile across patient tissues and cancer cell-line models. GPR143 expression is associated with patient survival in 26 of 34 cancer types, with the highest sampling consensus in UVM. Among the 18 cancer types available for tumor–normal comparison, GPR143 is differentially expressed in 11, with the highest sampling consensus in KIRP. Additionally, GPR143 RNA expression shows 14,996 significant gene co-expression associations, with the highest sampling consensus in TGCT. Together, these results highlight UVM, KIRP, and TGCT as cancer lineages where GPR143 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for GPR143 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes GPR143 survival associations across molecular data types. GPR143 RNA expression shows survival associations in the most cancer types (26), followed by mutation status (7) and mass-spec protein abundance (1). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible GPR143 RNA expression–survival associations across cancer types. High GPR143 expression shows unfavorable associations in UVM and SKCM, but favorable associations in ACC, LUAD, READ and HNSC. The UVM Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify UVM as the clearest survival context for GPR143 RNA expression.
This table summarizes GPR143 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 11. The strongest signals are observed in KIRP for RNA.
This table ranks reproducible tumor–normal expression differences for GPR143. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. GPR143 shows lower tumor expression in KIRC and higher tumor expression in KIRP, COAD, READ, BRCA and KICH. The KIRP box plot shows higher GPR143 RNA expression in tumor versus normal tissue (log2 FC = +2.067, t-test p < 0.001).
This table shows molecular features associated with GPR143 in patient tissues and cancer cell lines. In patient samples, GPR143 shows the broadest associations at the RNA and protein expression levels, with TGCT recurring as the lineage with the largest associated feature set. In cancer cell lines, GPR143 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LUNG_NSCLC_LUAD, while CRISPR and shRNA rows add functional-dependency signals in BLOOD_Leukemia and LUNG_SCLC.
