GPR143

Across TCGA patient cohorts, GPR143 mutation is significantly associated with the RNA expression of many other genes, with 2,093 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR143-associated genes across cancer lineages are RPS29P6, RNA5SP412, and FOXC2-AS1. Each is linked with GPR143 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR143-to-partner and partner-to-GPR143 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPS29P6 grouped by GPR143-low versus GPR143-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR143→partner) and Y-score (partner→GPR143) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RPS29P6 →	+0.536	+4.517	<.001	.001	3	2
LUSC	RNA5SP412 →	+0.491	+4.993	<.001	.003	3	2
SKCM	FOXC2-AS1 →	+0.384	+3.801	.004	.009	3	2
SKCM	NCMAP-DT →	+0.130	+4.287	<.001	.003	3	2
COAD	LINC01022 →	+0.356	+4.462	<.001	<.001	3	2
COAD	LINC00556 →	+0.262	+3.429	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,093 associations by consensus.

RPS29P6 by GPR143 expression — LUSC

Explore this box plot interactively →