GPR143

Across TCGA patient cohorts, GPR143 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPR143-associated genes across cancer lineages are Notch1, Annexin-1, and Cyclin-B1. Each is linked with GPR143 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR143-to-partner and partner-to-GPR143 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by GPR143-low versus GPR143-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR143→partner) and Y-score (partner→GPR143) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.178	+2.013	<.001	.016	3	2
UCEC	Annexin-1 →	+0.447	+1.874	.026	.049	3	2
UCEC	Cyclin-B1 →	+0.723	+2.087	<.001	.005	3	2
UCEC	EGFR_pY1068 →	-0.214	-2.087	.026	.005	3	1
UCEC	JNK_pT183_Y185 →	-0.167	-2.115	.009	.017	3	1
UCEC	JNK2 →	+0.224	+2.009	.003	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Notch1 by GPR143 expression — UCEC

Explore this box plot interactively →