GPR143

Across TCGA cell cohorts, GPR143 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible GPR143-associated genes across cancer lineages are OR12D3, DMRTB1, and CABS1. Each is linked with GPR143 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPR143-to-partner and partner-to-GPR143 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR12D3 grouped by GPR143-low versus GPR143-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPR143→partner) and Y-score (partner→GPR143) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR12D3 →	+0.025	+5.228	.001	.005	3	1
LUNG_NSCLC_LUAD	DMRTB1 →	+0.006	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	CABS1 →	+0.012	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	OPRPN →	+0.047	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR6T1 →	+0.042	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR1D4 →	+0.052	+5.662	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

OR12D3 by GPR143 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →