family with sequence similarity 76 member BGenealiases: []
Q-omics provides the consensus-scored FAM76B profile across patient tissues and cancer cell-line models. FAM76B expression is associated with patient survival in 28 of 34 cancer types, with the highest sampling consensus in ACC. Among the 18 cancer types available for tumor–normal comparison, FAM76B is differentially expressed in 13, with the highest sampling consensus in HNSC. Additionally, FAM76B protein abundance shows 25,428 significant protein co-abundance associations, with the highest sampling consensus in GBM. Together, these results highlight ACC, HNSC, and GBM as cancer lineages where FAM76B shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for FAM76B — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes FAM76B survival associations across molecular data types. FAM76B RNA expression shows survival associations in the most cancer types (28), followed by mutation status (3) and mass-spec protein abundance (10). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible FAM76B RNA expression–survival associations across cancer types. High FAM76B expression shows unfavorable associations in ACC, LGG and KICH, but favorable associations in BLCA, UCS and HNSC. The ACC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify ACC as the clearest survival context for FAM76B RNA expression.
This table summarizes FAM76B tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 13, while mass-spec protein shows differences in 9. The strongest signals are observed in HNSC for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for FAM76B. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. FAM76B shows lower tumor expression in THCA and higher tumor expression in HNSC, KIRC, BLCA, STAD and LUSC. The HNSC box plot shows higher FAM76B RNA expression in tumor versus normal tissue (log2 FC = +0.796, t-test p < 0.001).
This table shows molecular features associated with FAM76B in patient tissues and cancer cell lines. In patient samples, FAM76B shows the broadest associations at the RNA and protein expression levels, with GBM recurring as the lineage with the largest associated feature set. In cancer cell lines, FAM76B RNA and mutation anchors are most strongly linked to RNA-expression features, especially in OVARY, while CRISPR and shRNA rows add functional-dependency signals in BONE and BLOOD_Leukemia.
