FAM76B

Across TCGA patient cohorts, FAM76B mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM76B-associated genes across cancer lineages are eEF2, A-Raf_pS299, and FoxM1. Each is linked with FAM76B in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM76B-to-partner and partner-to-FAM76B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by FAM76B-low versus FAM76B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM76B→partner) and Y-score (partner→FAM76B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.437	+2.999	.005	.035	3	1
UCEC	A-Raf_pS299 →	-0.106	-3.321	.042	.010	3	1
UCEC	FoxM1 →	+0.266	+2.115	.018	.019	3	1
UCEC	ACC1 →	+0.316	+2.820	.046	.035	3	1
UCEC	INPP4B →	-0.443	-3.700	.001	.001	3	1
UCEC	JNK_pT183_Y185 →	-0.216	-2.794	.003	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

eEF2 by FAM76B expression — UCEC

Explore this box plot interactively →