DDB1 and CUL4 associated factor 12 like 1Genealiases: KIAA1892L · WDR40B
Q-omics provides the consensus-scored DCAF12L1 profile across patient tissues and cancer cell-line models. DCAF12L1 expression is associated with patient survival in 20 of 34 cancer types, with the highest sampling consensus in UCEC. Among the 18 cancer types available for tumor–normal comparison, DCAF12L1 is differentially expressed in 11, with the highest sampling consensus in COAD. Additionally, DCAF12L1 RNA expression shows 10,529 significant gene co-expression associations, with the highest sampling consensus in KIRP. Together, these results highlight UCEC, COAD, and KIRP as cancer lineages where DCAF12L1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for DCAF12L1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes DCAF12L1 survival associations across molecular data types. DCAF12L1 RNA expression shows survival associations in the most cancer types (20), followed by mutation status (9) and mass-spec protein abundance (3). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible DCAF12L1 RNA expression–survival associations across cancer types. High DCAF12L1 expression shows unfavorable associations in UCEC and LIHC, but favorable associations in KIRC, UCS, MESO and UVM. The UCEC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .001). Together, the overview and detailed table identify UCEC as the clearest survival context for DCAF12L1 RNA expression.
This table summarizes DCAF12L1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 11, while mass-spec protein shows differences in 3. The strongest signals are observed in COAD for RNA and COAD for protein.
This table ranks reproducible tumor–normal expression differences for DCAF12L1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. DCAF12L1 shows lower tumor expression in COAD, KICH, KIRC, THCA, BLCA and UCEC. The COAD box plot shows higher DCAF12L1 RNA expression in normal versus tumor tissue (log2 FC = −0.044, t-test p < 0.001).
This table shows molecular features associated with DCAF12L1 in patient tissues and cancer cell lines. In patient samples, DCAF12L1 shows the broadest associations at the RNA and protein expression levels, with KIRP recurring as the lineage with the largest associated feature set. In cancer cell lines, DCAF12L1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in KIDNEY, while CRISPR and shRNA rows add functional-dependency signals in LUNG_NSCLC_LUAD and LARGE_INTESTINE.
