Across TCGA pan-cancer cohorts, DCAF12L1 mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of DCAF12L1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where DCAF12L1 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types DCAF12L1 is over-expressed in tumor, although a few such as COAD and OV show the opposite, repressed pattern.

COAD, OV, and LUAD are the cancer types where DCAF12L1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DCAF12L1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	All	−1.123	<.001	7	view →
OV	All	All	−1.780	.015	2	view →
LUAD	Female	All	+1.068	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: DCAF12L1 RNA expression & survival · all DCAF12L1 data types