Across TCGA pan-cancer cohorts, DCAF12L1 Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated DCAF12L1 data layer compared with 20 for mass-spec protein and 3 for mass-spec protein.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher DCAF12L1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated DCAF12L1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.
HNSC, LUAD, and DLBC are the cancer types where DCAF12L1 Mutation most reproducibly stratifies survival.
Mutation survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.