Across TCGA pan-cancer cohorts, DCAF12L1 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated DCAF12L1 data layer compared with 20 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher DCAF12L1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated DCAF12L1 expression acts as an unfavorable survival marker, although some lineages such as OV show a favorable association.

LSCC, OV, and CCRCC are the cancer types where DCAF12L1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	II,III,IV	0.442	1.000	.014	10	view →
OV	DFS	Median	All	0.942	0.568	.005	8	view →
CCRCC	DFS	Quartile	II,III,IV	0.104	1.000	.038	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: DCAF12L1 tumor-vs-normal RNA expression · all DCAF12L1 data types