Across TCGA patient cohorts, COX8C mutation is significantly associated with the RNA expression of many other genes, with 29 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible COX8C-associated genes across cancer lineages are RNA5SP189, RNU1-139P, and USP9YP10. Each is linked with COX8C in more than 1 cancer types. Because this analysis shows association rather than direction, both COX8C-to-partner and partner-to-COX8C results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COX8C→partner) and Y-score (partner→COX8C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNA5SP189 →	+0.502	+7.924	<.001	.008	3	1
LUSC	RNU1-139P →	+0.518	+7.924	<.001	.008	3	1
LUSC	USP9YP10 →	+0.064	+7.924	<.001	.008	3	1
LUSC	RNU7-87P →	+0.763	+7.924	<.001	.008	3	1
LUSC	RN7SL343P →	+0.144	+7.924	<.001	.008	3	1
UCEC	PRAMEF13 →	+0.066	+4.716	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Exploration

COX8C survival (RNA) · tumor vs normal (RNA) · all COX8C data types