Across TCGA pan-cancer cohorts, COX8C RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated COX8C data layer compared with 2 for mutation status.
The strongest signal is observed in uterine carcinosarcoma (UCS), where higher COX8C RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated COX8C expression acts as an unfavorable survival marker, although some lineages such as UCS and CESC show a favorable association.
UCS, MESO, and CESC are the cancer types where COX8C RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.