Across TCGA pan-cancer cohorts, COX8C RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of COX8C’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where COX8C RNA is repressed in tumor relative to normal tissue. In most cancer types COX8C is over-expressed in tumor, although a few such as KICH and COAD show the opposite, repressed pattern.

KICH, COAD, and KIRC are the cancer types where COX8C tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in COX8C RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	All	−0.179	<.001	4	view →
COAD	Male	IV	−0.174	.027	2	view →
KIRC	All	III,IV	−0.081	.028	1	view →
HNSC	All	III,IV	+0.074	.035	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: COX8C RNA expression & survival · all COX8C data types