centrobin, centriole duplication and spindle assembly proteinGenealiases: LIP8 · PP1221
Q-omics provides the consensus-scored CNTROB profile across patient tissues and cancer cell-line models. CNTROB expression is associated with patient survival in 21 of 34 cancer types, with the highest sampling consensus in ACC. Among the 18 cancer types available for tumor–normal comparison, CNTROB is differentially expressed in 14, with the highest sampling consensus in HNSC. Additionally, CNTROB RNA expression shows 19,528 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight ACC, and HNSC as cancer lineages where CNTROB shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for CNTROB — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes CNTROB survival associations across molecular data types. CNTROB RNA expression shows survival associations in the most cancer types (21), followed by mutation status (8) and mass-spec protein abundance (3). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible CNTROB RNA expression–survival associations across cancer types. High CNTROB expression shows unfavorable associations in ACC, MESO, KICH, KIRC and LUSC, but favorable associations in BRCA. The ACC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify ACC as the clearest survival context for CNTROB RNA expression.
This table summarizes CNTROB tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 14, while mass-spec protein shows differences in 3. The strongest signals are observed in HNSC for RNA and LUAD for protein.
This table ranks reproducible tumor–normal expression differences for CNTROB. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. CNTROB shows lower tumor expression in LUAD and KICH and higher tumor expression in HNSC, KIRC, KIRP and LIHC. The HNSC box plot shows higher CNTROB RNA expression in tumor versus normal tissue (log2 FC = +1.050, t-test p < 0.001).
This table shows molecular features associated with CNTROB in patient tissues and cancer cell lines. In patient samples, CNTROB shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set. In cancer cell lines, CNTROB RNA and mutation anchors are most strongly linked to RNA-expression features, especially in KIDNEY, while CRISPR and shRNA rows add functional-dependency signals in LUNG_NSCLC_LUAD and BLOOD_Leukemia.
