CNTROB

Across TCGA cell cohorts, CNTROB mutation is significantly associated with the RNA expression of many other genes, with 33 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CNTROB-associated genes across cancer lineages are STH, DAZ2, and CT47A6. Each is linked with CNTROB in more than 1 cancer types. Because this analysis shows association rather than direction, both CNTROB-to-partner and partner-to-CNTROB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STH grouped by CNTROB-low versus CNTROB-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNTROB→partner) and Y-score (partner→CNTROB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	STH →	+0.065	+3.874	<.001	.005	3	2
OVARY	DAZ2 →	+0.106	+5.807	<.001	.001	3	1
OVARY	CT47A6 →	+0.030	+5.807	<.001	.001	3	1
SKIN	FAM71C →	+0.012	+4.095	.008	.009	3	1
SKIN	UGT2B11 →	+0.047	+4.930	<.001	.001	3	1
BLOOD_Leukemia	TNP1 →	+0.134	+4.984	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

STH by CNTROB expression — BLOOD_Leukemia

Explore this box plot interactively →