CNTROB

Across TCGA patient cohorts, CNTROB mutation is significantly associated with the RNA expression of many other genes, with 1,669 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CNTROB-associated genes across cancer lineages are OR11H1, RPL23AP82, and RPS27L. Each is linked with CNTROB in more than 1 cancer types. Because this analysis shows association rather than direction, both CNTROB-to-partner and partner-to-CNTROB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR11H1 grouped by CNTROB-low versus CNTROB-high in LGG.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNTROB→partner) and Y-score (partner→CNTROB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LGG	OR11H1 →	+0.044	+7.977	<.001	.007	3	2
UCEC	RPL23AP82 →	+0.325	+2.828	.002	.001	3	2
UCEC	RPS27L →	+0.639	+3.021	<.001	<.001	3	2
UCEC	PDCD1 →	+1.041	+2.295	<.001	<.001	3	2
UCEC	GM2A →	+0.400	+2.743	.001	.002	3	2
UCEC	KRTAP20-3 →	+0.059	+3.945	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,669 associations by consensus.

OR11H1 by CNTROB expression — LGG

Explore this box plot interactively →