CNTROB

Across TCGA patient cohorts, CNTROB mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CNTROB-associated genes across cancer lineages are PCNA, Shc_pY317, and TFRC. Each is linked with CNTROB in more than 1 cancer types. Because this analysis shows association rather than direction, both CNTROB-to-partner and partner-to-CNTROB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by CNTROB-low versus CNTROB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNTROB→partner) and Y-score (partner→CNTROB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.266	+2.502	<.001	.001	3	2
UCEC	Shc_pY317 →	-0.214	-3.700	<.001	.001	3	2
UCEC	TFRC →	+0.518	+2.700	.005	.005	3	2
UCEC	Tuberin →	+0.204	+1.874	.032	.049	3	2
UCEC	ATM →	-0.586	-2.000	<.001	.003	3	2
UCEC	Cyclin-B1 →	+0.656	+2.392	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

PCNA by CNTROB expression — UCEC

Explore this box plot interactively →