cilia and flagella associated protein 57Genealiases: SPGF95 · VWS2 · WDR65
Q-omics provides the consensus-scored CFAP57 profile across patient tissues and cancer cell-line models. CFAP57 expression is associated with patient survival in 23 of 34 cancer types, with the highest sampling consensus in UVM. Among the 18 cancer types available for tumor–normal comparison, CFAP57 is differentially expressed in 13, with the highest sampling consensus in KICH. Additionally, CFAP57 RNA expression shows 16,599 significant gene co-expression associations, with the highest sampling consensus in KIRP. Together, these results highlight UVM, KICH, and KIRP as cancer lineages where CFAP57 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for CFAP57 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes CFAP57 survival associations across molecular data types. CFAP57 RNA expression shows survival associations in the most cancer types (23), followed by mutation status (8) and mass-spec protein abundance (2). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible CFAP57 RNA expression–survival associations across cancer types. High CFAP57 expression shows unfavorable associations in LGG and ACC, but favorable associations in UVM, BRCA, UCEC and KIRP. The UVM Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p = .001). Together, the overview and detailed table identify UVM as the clearest survival context for CFAP57 RNA expression.
This table summarizes CFAP57 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 13, while mass-spec protein shows differences in 2. The strongest signals are observed in KIRC for RNA and LUAD for protein.
This table ranks reproducible tumor–normal expression differences for CFAP57. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. CFAP57 shows lower tumor expression in KICH, KIRC, THCA, LUSC and LUAD and higher tumor expression in BRCA. The KICH box plot shows higher CFAP57 RNA expression in normal versus tumor tissue (log2 FC = −1.277, t-test p < 0.001).
This table shows molecular features associated with CFAP57 in patient tissues and cancer cell lines. In patient samples, CFAP57 shows the broadest associations at the RNA and protein expression levels, with KIRP recurring as the lineage with the largest associated feature set. In cancer cell lines, CFAP57 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in BONE, while CRISPR and shRNA rows add functional-dependency signals in BREAST and BLOOD_Lymphoma.
