CFAP57

Across TCGA patient cohorts, CFAP57 mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CFAP57-associated genes across cancer lineages are eIF4E, ATM, and BRD4. Each is linked with CFAP57 in more than 2 cancer types. Because this analysis shows association rather than direction, both CFAP57-to-partner and partner-to-CFAP57 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by CFAP57-low versus CFAP57-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CFAP57→partner) and Y-score (partner→CFAP57) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.150	+2.598	.034	.005	3	2
UCEC	ATM →	-0.592	-2.401	<.001	.002	3	2
UCEC	BRD4 →	+0.184	+1.807	.040	.023	3	2
UCEC	Caspase-7-cleavedD198 →	+0.662	+2.604	<.001	<.001	3	2
UCEC	4E-BP1 →	+0.287	+3.936	.001	<.001	3	2
SKCM	c-Kit →	-0.522	-2.000	.037	.029	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

eIF4E by CFAP57 expression — UCEC

Explore this box plot interactively →