CFAP57

Across TCGA pan-cancer cohorts, CFAP57 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated CFAP57 data layer compared with 8 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher CFAP57 RNA is associated with better overall survival. In most high-consensus cancer types, elevated CFAP57 expression acts as an unfavorable survival marker, although some lineages such as UVM and BRCA show a favorable association.

UVM, BRCA, and LGG are the cancer types where CFAP57 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Quartile	II,III,IV	0.853	0.381	.001	73	view →
BRCA	OS	Tertile	III,IV	0.898	0.736	.003	68	view →
LGG	DFS	Median	All	0.307	0.499	<.001	49	view →
UCEC	OS	Quartile	III,IV	0.913	0.709	.003	26	view →
ACC	DFS	Quartile	All	0.217	0.615	.004	22	view →
KIRP	DFS	Median	All	0.976	0.805	.012	18	view →
ESCA	DFS	Tertile	All	1.000	0.571	.030	13	view →
MESO	DFS	Tertile	IV	0.264	0.623	.020	12	view →
STAD	OS	Median	II,III,IV	0.726	0.590	.022	11	view →
LUAD	OS	Tertile	All	0.901	0.767	.004	10	view →
LIHC	OS	Quartile	III,IV	0.797	0.562	.014	10	view →
SKCM	DFS	Median	IV	0.763	0.187	.006	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

CFAP57–UVM (OS)

Open the UVM breakdown →