caspase recruitment domain family member 11Genealiases: BENTA · BIMP3 · CARMA1 · IMD11 · IMD11A · PPBL
Q-omics provides the consensus-scored CARD11 profile across patient tissues and cancer cell-line models. CARD11 expression is associated with patient survival in 26 of 34 cancer types, with the highest sampling consensus in UVM. Among the 18 cancer types available for tumor–normal comparison, CARD11 is differentially expressed in 15, with the highest sampling consensus in KIRC. Additionally, CARD11 RNA expression shows 16,952 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight UVM, and KIRC as cancer lineages where CARD11 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for CARD11 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes CARD11 survival associations across molecular data types. CARD11 RNA expression shows survival associations in the most cancer types (26), followed by mutation status (11) and mass-spec protein abundance (3). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible CARD11 RNA expression–survival associations across cancer types. High CARD11 expression shows unfavorable associations in UVM, LGG and KIRC, but favorable associations in SKCM, BLCA and CHOL. The UVM Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify UVM as the clearest survival context for CARD11 RNA expression.
This table summarizes CARD11 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 15, while mass-spec protein shows differences in 4. The strongest signals are observed in KIRC for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for CARD11. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. CARD11 shows higher tumor expression in KIRC, LUAD, HNSC, KIRP, CHOL and STAD. The KIRC box plot shows higher CARD11 RNA expression in tumor versus normal tissue (log2 FC = +2.014, t-test p < 0.001).
This table shows molecular features associated with CARD11 in patient tissues and cancer cell lines. In patient samples, CARD11 shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set. In cancer cell lines, CARD11 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in PANCREAS, while CRISPR and shRNA rows add functional-dependency signals in LUNG_NSCLC_LUSC and BLOOD_Lymphoma.
