Across TCGA cell cohorts, CARD11 mutation is significantly associated with the RNA expression of many other genes, with 1,028 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CARD11-associated genes across cancer lineages are CASP6, NEUROG1, and CEP192. Each is linked with CARD11 in more than 2 cancer types. Because this analysis shows association rather than direction, both CARD11-to-partner and partner-to-CARD11 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CARD11→partner) and Y-score (partner→CARD11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CASP6 →	+0.711	+2.614	.001	.003	3	3
PANCREAS	NEUROG1 →	+0.032	+4.614	<.001	.004	3	2
SKIN	CEP192 →	+0.553	+3.212	<.001	.006	3	2
SKIN	NAPG →	+0.469	+3.212	.006	.006	2	3
SKIN	AFG1L →	+0.627	+3.212	<.001	.006	3	2
LUNG_SCLC	OR10A5 →	+0.056	+3.817	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,028 associations by consensus.

Exploration

CARD11 survival (RNA) · tumor vs normal (RNA) · all CARD11 data types