Across TCGA patient cohorts, CARD11 RNA expression is significantly associated with the protein abundance of many other proteins, with 15,600 significant associations in total. GBM shows the largest number of these associations.

The most reproducible CARD11-associated proteins across cancer lineages are CARD11_S925, NFATC2, and TWF2. Each is linked with CARD11 in more than 7 cancer types. Because this analysis shows association rather than direction, both CARD11-to-partner and partner-to-CARD11 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CARD11→partner) and Y-score (partner→CARD11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CARD11_S925 →	+1.163	+1.526	<.001	<.001	3	8
HNSC	NFATC2 →	+0.433	+0.928	<.001	<.001	3	8
LSCC	TWF2 →	+0.325	+0.950	<.001	.004	3	7
GBM	ARPC1B →	+0.647	+0.893	<.001	<.001	3	7
BRCA	ARPC5 →	+0.376	+0.873	<.001	<.001	3	7
BRCA	SERPINB9 →	+0.502	+0.823	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,600 associations by consensus.

Exploration

CARD11 survival (RNA) · tumor vs normal (RNA) · all CARD11 data types