Across TCGA patient cohorts, CARD11 mutation is significantly associated with the total protein of many other genes, with 63 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CARD11-associated genes across cancer lineages are PKC-b-II_pS660, Cyclin-E2, and GAPDH. Each is linked with CARD11 in more than 3 cancer types. Because this analysis shows association rather than direction, both CARD11-to-partner and partner-to-CARD11 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CARD11→partner) and Y-score (partner→CARD11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PKC-b-II_pS660 →	-0.308	-1.807	.046	.026	3	4
LUAD	Cyclin-E2 →	+0.194	+3.476	<.001	.002	3	4
COAD	GAPDH →	+0.572	+2.511	.001	.001	3	4
COAD	ASNS →	+0.396	+3.807	.004	<.001	3	4
LUAD	PKC-a_pS657 →	-0.326	-3.288	.008	.009	3	3
COAD	c-Kit →	-0.594	-2.222	.005	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 63 associations by consensus.

Exploration

CARD11 survival (RNA) · tumor vs normal (RNA) · all CARD11 data types