Q-omics provides the consensus-scored C8orf48 profile across patient tissues and cancer cell-line models. C8orf48 expression is associated with patient survival in 22 of 34 cancer types, with the highest sampling consensus in LUAD. Among the 18 cancer types available for tumor–normal comparison, C8orf48 is differentially expressed in 9, with the highest sampling consensus in THCA. Additionally, C8orf48 RNA expression shows 15,909 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight LUAD, THCA, and UVM as cancer lineages where C8orf48 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for C8orf48 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes C8orf48 survival associations across molecular data types. C8orf48 RNA expression shows survival associations in the most cancer types (22), followed by mutation status (3). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible C8orf48 RNA expression–survival associations across cancer types. High C8orf48 expression shows unfavorable associations in LGG, STAD, MESO and KIRP, but favorable associations in LUAD and BRCA. The LUAD Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p = .009). Together, the overview and detailed table identify LUAD as the clearest survival context for C8orf48 RNA expression.
This table summarizes C8orf48 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 9. The strongest signals are observed in THCA for RNA.
This table ranks reproducible tumor–normal expression differences for C8orf48. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. C8orf48 shows lower tumor expression in THCA, KICH, UCEC, LUSC and LUAD and higher tumor expression in KIRP. The THCA box plot shows higher C8orf48 RNA expression in normal versus tumor tissue (log2 FC = −1.470, t-test p < 0.001).
This table shows molecular features associated with C8orf48 in patient tissues and cancer cell lines. In patient samples, C8orf48 shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set. In cancer cell lines, C8orf48 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LUNG_SCLC, while CRISPR and shRNA rows add functional-dependency signals in LIVER and SOFT_TISSUE.
