C8orf48

Across TCGA patient cohorts, C8orf48 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C8orf48-associated genes across cancer lineages are ATM, IGFBP2, and PCNA. Each is linked with C8orf48 in more than 1 cancer types. Because this analysis shows association rather than direction, both C8orf48-to-partner and partner-to-C8orf48 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by C8orf48-low versus C8orf48-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C8orf48→partner) and Y-score (partner→C8orf48) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.371	-2.321	.047	.006	3	2
UCEC	IGFBP2 →	-0.779	-1.807	.003	.027	3	1
UCEC	PCNA →	+0.196	+1.807	.028	.027	3	1
UCEC	Rad50 →	-0.201	-1.807	.045	.027	3	1
UCEC	Annexin-1 →	+0.610	+2.321	.005	.006	3	1
UCEC	Caspase-8 →	-0.241	-2.673	.020	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

ATM by C8orf48 expression — UCEC

Explore this box plot interactively →