C8orf48

Across TCGA cell cohorts, C8orf48 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. CNS shows the largest number of these associations.

The most reproducible C8orf48-associated genes across cancer lineages are FAM9A, HTR5A, and CCDC196. Each is linked with C8orf48 in more than 1 cancer types. Because this analysis shows association rather than direction, both C8orf48-to-partner and partner-to-C8orf48 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM9A grouped by C8orf48-low versus C8orf48-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C8orf48→partner) and Y-score (partner→C8orf48) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	FAM9A →	+0.039	+5.169	<.001	.005	3	1
CNS	HTR5A →	+0.027	+3.887	<.001	.001	3	1
CNS	CCDC196 →	+0.028	+4.459	<.001	<.001	3	1
CNS	CYP2A13 →	+0.021	+3.459	.001	.006	3	1
CNS	KRT31 →	+0.036	+4.196	<.001	.001	3	1
BLOOD_Leukemia	OR4L1 →	+0.016	+5.969	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

FAM9A by C8orf48 expression — BREAST

Explore this box plot interactively →