C8orf48

Across TCGA patient cohorts, C8orf48 mutation is significantly associated with the RNA expression of many other genes, with 1,817 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C8orf48-associated genes across cancer lineages are ATP5F1A, TRMT44, and EOMES. Each is linked with C8orf48 in more than 1 cancer types. Because this analysis shows association rather than direction, both C8orf48-to-partner and partner-to-C8orf48 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATP5F1A grouped by C8orf48-low versus C8orf48-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C8orf48→partner) and Y-score (partner→C8orf48) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATP5F1A →	+0.533	+2.513	.001	.001	3	2
UCEC	TRMT44 →	+0.312	+3.232	.003	.009	3	2
UCEC	EOMES →	+0.436	+2.609	.005	.005	3	2
UCEC	ABHD18 →	+0.468	+2.606	<.001	.005	3	2
UCEC	R3HCC1L →	+0.443	+3.180	.002	<.001	3	2
UCEC	NIPA1 →	+0.782	+2.807	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,817 associations by consensus.

ATP5F1A by C8orf48 expression — UCEC

Explore this box plot interactively →